High Frequency Chest Wall Oscillations Versus Lung Flute in Chronic Obstructive Pulmonary Disease Post(SARS-CoV-2)

Cairo University (CU)

Status: Enrolling

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Device: high frequency chest wall oscillation with vest system; Device: Lung flute (OPEP)

Study type: Interventional

Funder types: Other

Identifiers

NCT05591781

P.T.REC/012/003822

Details and patient eligibility

About

COPD causes an acute deterioration of respiratory symptoms, particularly increased breathlessness and cough, and increased sputum volume and/or purulence. Worsening airflow limitation is associated with an increasing prevalence of exacerbations and risk of death. These exacerbations can range from self-limited diseases to episodes of florid respiratory failure requiring mechanical ventilation .Hospitalization for COPD patients post COVID is associated with poor prognosis with increased risk of death. Hence techniques of efficient clearance of peripheral airways may reduce airway occlusion by excess mucus and inflammatory cells, improving lung function, exercise capacity and reducing exacerbation frequency.

Full description

Patients were assigned to 2 groups with pre- and post- treatment protocol application. All patients were thoroughly evaluated before and after treatment protocol application. Thirty patients (Group A) received high frequency chest wall oscillation with vest system in addition to their prescribed medication, 3 times per week for three successive weeks and the total duration of each session was 15-30 minutes. Thirty patients (Group B) received Lung flute (OPEP) in addition to their prescribed medication, 2 times per week twice a day for three successive weeks and the total duration of each session was 10-15 minutes

Enrollment: 60 estimated patients

Sex: Male

Ages: 40 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients aged 40-60 years old
• All patients were recovered from COVID not more than 3 months
• All patients were diagnosed as COPD for at least two years ago.
• All patients had irreversible/ partially reversible obstruction of airflow.
• COPD patients had a post-bronchodilator, FEV1/FVC% < 70%. They had an increase in FEV1< 200 ml, or < 12% of baseline value 20 minutes after 2 puffs of inhaled salbutamol (100 µg) given via a metered-dose inhaler.

Exclusion criteria

• Presence of malignant disease.

  • Patients with acute infection.
  • History of osteoporosis, significant gastro-oesophageal reflux, hiatus hernia.
  • Recent acute cardiac event (6 weeks) or congestive cardiac failure.
  • Any significant musculoskeletal disorders.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Vest Airway Clearance System

Experimental group

Description:

Thirty patients (Group A) received high frequency chest wall oscillation with vest system in addition to their prescribed medication, 3 times per week for three successive weeks and the total duration of each session was 15-30 minutes

Treatment:

Device: high frequency chest wall oscillation with vest system

Lung flute (OPEP)

Active Comparator group

Description:

Thirty patients (Group B) received Lung flute (OPEP) in addition to their prescribed medication, 3 times per week twice a day

Treatment:

Device: Lung flute (OPEP)