High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome

Groupe Hospitalier Pitie-Salpetriere

Status and phase: Completed; Phase 1

Conditions: Tourette's Syndrome

Treatments: Device: high frequency stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT00139308

RBM0008

Details and patient eligibility

About

Tourette's syndrome is a disabling neuropsychiatric disorder with major psychosocial consequences in some patients. The pathophysiology is still unknown. Some data suggest an dysfunction of limbic circuits in basal ganglia. The aim of this study is to evaluate the effect of high frequency stimulation of the internal part of the globus pallidus and/or parafascicular-median centre of the thalamus, two structures implicated in the limbic circuit, in patients with severe Tourette's syndrome.

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Tourette's syndrome (DSM IV)
• inducing a disability in the social and personal life
• No improvement with medical treatment
• Severe self suffering

Exclusion criteria

• Cognitive impairment (MMS < 24)
• Depression

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind