High Fresh Gas Flow After Intubation

Region Västmanland

Status: Completed

Conditions: Atelectasis

Treatments: Procedure: High fresh gas flow, high minute ventilation; Procedure: Control group, conventional ventilatory settings

Study type: Interventional

Funder types: Other

Identifiers

NCT02216006

Dnr 2012/335

Details and patient eligibility

About

Atelectasis is common during and after general anesthesia. Atelectasis develops early if preoxygenation with 100% oxygen is used and continuously used during induction until endotracheal intubation. The investigators hypothesize that a rapid anti-preoxygenation maneuver immediately after confirming a successful intubation, reduces the area of atelectasis as investigated by computed tomography compared to a standard procedure.

Enrollment: 24 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy patients, American Society of Anesthesiology (ASA) I-II
• Patients scheduled for orthopaedic day case surgery in general anaesthesia

Exclusion criteria

• ASA class III or higher
• Body Mass Index (BMI) 30 or higher
• Arterial oxygen saturation (SpO2) <94% breathing air
• Chronic Obstructive Pulmonary Disease (COPD)
• Ischemic heart disease
• Haemoglobin <100g/L
• Known or anticipated difficult airway and/or intubation
• Active smokers and ex-smokers with a history of more than 6 pack years
• Need for interscalene or supraclavicular regional anaesthesia with risk of phrenic nerve paralysis

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups

Control group, conventional ventilatory settings

Active Comparator group

Description:

Handling of the airway during induction and intubation is performed in a conventional manner. Initial ventilatory settings are also done in a conventional manner.

Treatment:

Procedure: Control group, conventional ventilatory settings

High fresh gas flow, high minute ventilation

Active Comparator group

Description:

Handling of the airway during induction and intubation is performed in a conventional manner. Immediately after confirming a successful intubation the effect of preoxygenation is eliminated with an anti-preoxygenation maneuver.

Treatment:

Procedure: High fresh gas flow, high minute ventilation