High Fructose Corn Syrup

The Washington University

Status: Completed

Conditions: Nonalcoholic Fatty Liver Disease; Obesity

Treatments: Behavioral: Standard diet (low in high fructose corn syrup); Behavioral: High fructose corn syrup diet

Study type: Interventional

Funder types: Other

Identifiers

NCT02018237

2011-12111

Details and patient eligibility

About

The purpose of this research study is to learn more about how high fructose corn syrup, a sugar used to sweeten drinks and foods, affects metabolism in obese persons with and without nonalcoholic fatty liver disease. Eligible participants will be studied before and after eating a diet high in high fructose corn syrup or a standard diet (low in high fructose corn syrup) for four weeks.

Enrollment: 47 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• IHTG >6.5% or <5%
• BMI 30.0-45.0 kg/m²
• Sedentary
• Consume <10% calories from high fructose corn syrup
• Weight stable for previous 3 months

Exclusion criteria

• IHTG 5.1-7.9%
• Children
• Adults over 65 years
• Pregnant
• Lactating
• Exercise >1.5 hours/week
• Hepatitis B or C
• Diabetes
• History of liver disease
• History of alcohol abuse
• Severe hypertriglyceridemia (>300 mg/dl)
• Smokers
• Anemia (Hemoglobin <10mg/dl)
• Not weight stable

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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47 participants in 2 patient groups

NAFLD

Active Comparator group

Description:

Subjects with nonalcoholic fatty liver disease (NAFLD) will complete baseline testing and then be assigned to either the high fructose corn syrup diet or the standard diet (low in high fructose corn syrup) for 4 weeks. Post intervention testing will be completed after the subjects have completed the 4 week diet intervention.

Treatment:

Behavioral: Standard diet (low in high fructose corn syrup)

Behavioral: High fructose corn syrup diet

Non-NAFLD

Active Comparator group

Description:

Subjects without nonalcoholic fatty liver disease (Non-NAFLD) will complete baseline testing and then be fed a high fructose corn syrup diet for 4 weeks. Post intervention testing will be completed after the subjects have completed the 4 week diet intervention.

Treatment:

Behavioral: High fructose corn syrup diet