High-Intensity Aerobic Interval Training in Testicular Cancer Survivors (HIITTS)

University of Alberta

Status: Completed

Conditions: Cardiovascular Diseases; Testicular Neoplasms

Treatments: Behavioral: High-intensity aerobic interval exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02459132

HREBA.CC-14-0183

Details and patient eligibility

About

This study evaluates the impact of a supervised 12-week high-intensity aerobic interval exercise program (versus a self-directed exercise usual care group) on traditional and novel cardiovascular disease risk factors and surrogate markers of cardiovascular- and overall-mortality in a population-based sample of testicular cancer survivors.

Enrollment: 63 patients

Sex: Male

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically confirmed history of testicular cancer

Exclusion criteria

• Not sufficiently ambulatory to complete the first two stages of the aerobic exercise test.
• Have a psychiatric condition which impairs their ability to perform the required volume and intensity of exercise.
• Have any uncontrolled cardiovascular condition (i.e. heart disease, hypertension, diabetes, arrhythmia).
• Report performing any weekly vigorous intensity aerobic exercise in the past month.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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63 participants in 2 patient groups

Exercise Group

Experimental group

Description:

Subjects in the exercise group will attend supervised exercise sessions three times a week, for 12 weeks. The exercise intervention will consist of uphill walking or jogging on a treadmill between 50% and 95% of VO2peak for 35 minutes (including a 5-minute warm up and cool down). The participants will complete four, 4-minute, high-intensity intervals at 85-95% of VO2peak. The work period intervals will be interspersed with three, 3-minute periods of active recovery at an intensity below that of their ventilatory threshold.

Treatment:

Behavioral: High-intensity aerobic interval exercise

Usual Care

No Intervention group

Description:

The usual care group will not receive an intervention, and they will be asked to maintain baseline physical activity levels throughout the observation period.