High-Intensity Exercise in Older Adults

University of California (UC), Berkeley

Status: Completed

Conditions: Functional Fitness; Cognitive Abilities

Treatments: Behavioral: APEX

Study type: Interventional

Funder types: Other

Identifiers

NCT06199661

1884

Details and patient eligibility

About

The goal of this interventional study was to test the high-intensity interval training called Aphasia Physical Exercise (APEX) in healthy older adults. The main questions it aimed to answer were:

1. what is the safety and feasibility of APEX?
2. what are APEX's acute physiological effects?
3. what is APEX's effects on functional fitness?
4. what is APEX's effects on cognition?

Participants underwent:

• Baseline testing session (#1) with cognitive measures only (a week before the Pre-exercise session);
• Pre-exercise session (#2) with maximum oxygen consumption and heart rate assessment, functional fitness and cognitive measures (3-7 days before the start of the exercise program);
• APEX program, two APEX classes per week for four weeks (eight classes in total);
• Post-exercise session (#3), functional fitness and cognitive measures, (0-2 days after the end of the exercise program).

Enrollment: 4 patients

Sex: All

Ages: 50 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between the ages of 50 and 80
• Ambulatory and community-dwelling
• Able to travel to University of San Francisco for weekly exercise classes
• No serious underlying health or neurological conditions

Exclusion criteria

• Inability to complete physical function assessment or inability to do a chair stand without using hands
• Use of antidiabetic medications
• Use of testosterone supplement or replacement
• Clinical disorder precluding/interfering with participation or assessments (identified by Physical Activity Readiness Questionnaire (PAR-Q+)), including: unstable angina, arrhythmia, uncontrolled hypertension, end stage renal disease on hemodialysis, lower extremity amputation or paralysis, neurological conditions causing functional or pronounced cognitive impairments, active malignancy except for non-melanomatous skin cancers
• Previous neurological history such as stroke, traumatic brain injury, multiple sclerosis, long-term pre-stroke seizures, Parkinson's, Alzheimer's, etc.
• Unable to provide consent

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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4 participants in 1 patient group

APEX

Experimental group

Description:

Physical exercise intervention based on high-intensity interval training

Treatment:

Behavioral: APEX