High Intensity Interval Training and Hypoxic Conditioning in Obese Patients (HYPINT)

Grenoble Alpes University Hospital Center (CHU)

Status: Unknown

Conditions: Obesity

Treatments: Other: Constant load exercise training N; Other: High intensity interval training N; Other: Normoxic conditioning at rest; Other: Hypoxic conditioning at rest; Other: Constant load exercise training H; Other: High intensity interval training H

Study type: Interventional

Funder types: Other

Identifiers

NCT02642705

2014-A01482-45

Details and patient eligibility

About

The present study aims at evaluating the effect of two innovative treatment strategies in obese patients: high intensity interval training and hypoxic conditioning. Obese patients will be randomized in groups performing high intensity interval training, constant load training, hypoxic conditioning or placebo normoxic conditioning for 8 weeks. The effects of the interventions will be measured regarding exercise tolerance, blood pressure, body composition, metabolic status.

Full description

120 obese patients will be randomized to 6 intervention groups. Each group will follow an 8-week intervention (3 session per week) with either high intensity interval training in normoxia or hypoxia, constant load exercise training in normoxia or hypoxia, hypoxic or normoxic (placebo) conditioning at rest. Exercise capacity, metabolic status, blood pressure, vascular function and physical activity will be assessed before and after the intervention.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI between 27 and 35 kg/m²
• Physical activity <2 hours/week
• No chronic disease or treatment able to interfere with inflammation and metabolic perturbatiosn associated with obesity

Exclusion criteria

• Diabetes mellitus treated with insulin
• Auto-immune or inflammatory diseases requiring long term therapy
• Unstable dysthyroidism
• Bariatric surgery within the past 18 months
• Tumoral, inflammatory, infectious, cardiac, respiratory, kidney, digestive disease
• Untreated sleep apnea

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 6 patient groups

High intensity interval training N

Experimental group

Description:

High intensity interval training N: The intervention consists in 8-week exercise training, 3 times a week for one hour, according to a high intensity interval training protocol (1 min ON at 100% maximal power output, 1 min OFF), breathing ambient air (normoxia)

Treatment:

Other: High intensity interval training N

High intensity interval training H

Experimental group

Description:

High intensity interval training H: The intervention consists in 8-week exercise training, 3 times a week for one hour, according to a high intensity interval training protocol (1 min ON at 100% maximal power output, 1 min OFF), breathing hypoxic air (about 3 500 m of altitude)

Treatment:

Other: High intensity interval training H

Constant load exercise training N

Active Comparator group

Description:

Constant load exercise training N: The intervention consists in 8-week exercise training, 3 times a week for one hour, according to a constant load training protocol (50% maximal power output), breathing ambient air (normoxia)

Treatment:

Other: Constant load exercise training N

Constant load exercise training H

Experimental group

Description:

Constant load exercise training H: The intervention consists in 8-week exercise training, 3 times a week for one hour, according to a constant load training protocol (50% maximal power output), breathing hypoxic air (about 3 500 m of altitude)

Treatment:

Other: Constant load exercise training H

Hypoxic conditioning at rest

Experimental group

Description:

Hypoxic conditioning at rest : The intervention consists in 8-week conditioning period, 3 times a week, hypoxic breathing for one hour (about 4500 m of altitude) while seating quietly

Treatment:

Other: Hypoxic conditioning at rest

Normoxic conditioning at rest

Sham Comparator group

Description:

Normoxic conditioning at rest : The intervention consists in 8-week conditioning period, 3 times a week, normoxic breathing for one hour (ambient air) while seating quietly

Treatment:

Other: Normoxic conditioning at rest