High Intensity Interval Training and Skeletal Muscle Insulin Sensitivity

Maastricht University

Status

Completed

Conditions

Overweight and Obesity

Treatments

Behavioral: High-intenstiy interval training

Study type

Interventional

Funder types

Other

Identifiers

NCT03405545

NL62654.068.17

Details and patient eligibility

About

This human intervention study will test if 12 weeks of supervised HIIT-based intervention improves skeletal muscle NOGD capacity in obese subjects.

Full description

19 overweight-obese (BMI => 27kg/m2), sedentary females and males aged 45-75yr will be enrolled in this study.

Participants will train 3 times/week under supervision during 12 weeks. Before, after and during this 12-week training period, there will be multiple metabolic measurements.

Enrollment

19 patients

Sex

All

Ages

45 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Signed informed consent
Age 45 - 75 years old
Overweight to obese (BMI => 27kg/m2)
Sedentary - subjects do not perform any regular physical activity weekly(<3 times per week, <150 min/week).

Exclusion criteria

Unstable body weight (weight gain or loss > 3 kg in the past three months)
Participation in an intensive weight-loss program or in vigorous exercise program during the last year before starting the study.
HbA1c > 6.5% and glucose clearance rate >350 ml/kg/min (by OGTT).
Previously diagnosed with type 2 diabetes
Active cardiovascular disease. This will be determined by the questionnaires and by screening on medication.
Use of beta-blockers
Anticoagulant therapy
Systolic blood pressure >160 mmHg or diastolic blood pressure >100 mmHg
Abuse of alcohol (> 3 units (1 unit = 10 gr ethanol) per day)
Any contra-indication to Magnetic Resonance Imaging (MRI) scanning
Participation in another biomedical study within 1 month before the first study visit, which may interfere with the outcomes of the present study.
Use of any medication affecting the glucose homeostasis and whole body metabolism or diseases that may significantly interfere with the main aim of the study.
Chronic renal dysfunction (creatinine >2 increased (normal value 64-104 µmol/l)
Subjects who do not want to be informed about unexpected medical findings during the screening / study, or do not wish that their physician is informed, cannot participate in the study.
Subjects will be included only when the dependent medical doctor of this study approves participation after evaluating all data obtained during the screening.