High Intensity Interval Training (HIIT) for Patients With Cancer-related Lymphedema in the Lower Limbs

Herlev and Gentofte Hospital

Status

Completed

Conditions

Malignant Melanoma

Cancer, Ovarian

Cancer of Cervix

Cancer, Endometrial

Lymphedema of Leg

Cancer of the Prostate

Treatments

Other: First exercise session - compression

Other: First exercise session + compression

Study type

Interventional

Funder types

Other

Identifiers

NCT03653819

Lympha feasibility

Details and patient eligibility

About

The aim of the study is to explore the feasibility and safety of High Intensity Interval Training on a stationary bike for patients with lymphedema in the lower limbs and the role of compression garments during exercise.

The design of the study is a cross-over randomized clinical trial. Participants will be randomized into two groups. Both will perform two separate exercise sessions.Group A will perform the first exercise with compression garment and the second session without compression garment, with wash-out period of 1 week between sessions. Group B will perform the exercise sessions in the opposite order.

Full description

Lymphedema is a condition afflicting cancer patients who undergo surgery with removal of lymph nodes, chemotherapy and radiation. Lymphedema is a consequence of impaired lymphatic drainage in the interstitium, which causes edema and inflammation in the subcutaneous tissue. The symptoms are swelling, puffiness, tightness, heaviness and pain in the affected area.

Lymphedema can be reduced by complete decongestive therapy, which consists of skin care, manual lymphatic drainage, compression bandaging and exercise. At the end of treatment, patients are provided with custommade compression garments to be worn during daytime in order to maintain the reduction in the edema.

Lymphedema has a negative impact on activities of daily living and health-related quality of life. Patients with lymphedema should be encouraged to engage in physical activity despite their condition in order to prevent relapse of cancer and development of other diseases. Likewise physical activity helps to maintain a healthy weight, which is important as obesity has a negative impact on lymphedema. The lymphatic system is also stimulated by physical activity and exercise and can reduce the symptoms from the lymphedema.

Several studies have been published on the safety and benefits of exercise for women with breastcancer related lymphedema. However, only a few studies have investigated the feasibility of exercise to patients with lymphedema in the lower limbs. Also the role of compression garments during exercise have not been throughly explored.

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

unilateral or bilateral lymphedema in the lower limbs
secondary lymphedema
wears custommade compression stockings during daytime
lymphedema in stage 1, 2A or 2B (Classification from the International Society of Lymphology)
legally competent persons with ability to read and understand Danish.

Exclusion criteria

inability to perform the intervention, as assessed by the person performing inclusion.
lymphedema in stage 0 or 3 (Classification from the International Society of Lymphology)
ongoing complete decongestive lymphedema therapy
untreated erysipelas
ongoing oncologic treatment: chemotherapy, radiation, immune therapy,
known metastatic cancer
comorbidities e.g. deep venenous thrombosis, serious heart disease, renal insufficiency