High Intensity Interval Training in Osteoarthritis, Effects on Metabolomics

University of North Carolina (UNC)

Status

Completed

Conditions

Knee Osteoarthritis

Treatments

Behavioral: High intensity interval training

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT03039452

16-0829

1P2CHD086851-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Purpose: The purpose of this study will be to examine the feasibility and acceptability of a 6-week high intensity interval training (HIIT) program in patients with knee OA symptoms ranging from mild to severe. A secondary purpose will be to evaluated changes in whole body metabolism induced by 6-weeks of HIIT.

Participants: Fifteen patients (age 40-70 yrs; BMI 20-35 kg/m²) with symptomatic knee OA

Procedures (methods): All participants will be assigned to the single-arm of the study in which all participants will receive 6 weeks of HIIT, delivered twice per week. Outcomes will be assessed at baseline and 6 weeks. The primary outcome will evaluate tolerability, feasibility, acceptability, compliance, and adherence to the HIIT program. Secondary outcomes will include whole body metabolism markers, inflammation, and a set of physical function including knee osteoarthritis symptomatic burden and pain, cardiorespiratory fitness, isometric knee extensor and flexor strength (factors associated with physical function and symptomatic knee OA progression), and body composition.

Enrollment

15 patients

Sex

All

Ages

40 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Must exhibit symptomatic knee OA (WOMAC > 31), radiographic evidence of tibiofemoral OA (2-4 Kellgren-Lawrence scale)
Age 40-70 years
Body mass index 20-35 kg/m²
Cleared by study physician from 12 lead EKG and medical history review

Exclusion criteria

Individuals diagnosed with a cardiovascular condition restricting exercise Individuals currently meeting Department of Health and Human Services Guidelines for Physical Activity (meeting >150 minutes of exercise per week)
Individuals currently doing HIIT
Individuals currently participating in physical therapy for knee OA
Individuals currently participating in another OA intervention study
Received a corticosteroid or hyaluronic acid injection involved in the knee in the previous 3 weeks or scheduled for during the intervention
Diagnosis of gout in the knee
Diagnosis of Rheumatoid arthritis
Diagnosis of Fibromyalgia
Other systemic rheumatic disease
Severe dementia or other memory loss
Active diagnosis of psychosis or uncontrolled substance abuse disorder
Hospitalization for a stroke, heart attack, or heart failure, or had surgery for blocked arteries in the past 6 months
Diabetics (medications include exogenous insulin)
Total joint replacement knee surgery, other knee surgery, meniscus tear, or ACL tear in the past 12 months
On a waiting list for total joint replacement
Severely impaired hearing or speech
Pregnant or planning to become pregnant in the next 8 weeks
Inability to speak English
Serious or terminal illness as indicated by referral to hospice or palliative care
Nursing home residence
Inability to ride a stationary bike
Any other health problems that would prohibit safe participation in the study.