High-intensity Interval Versus Combined Exercise Training in CHF

National and Kapodistrian University of Athens

Status: Unknown

Conditions: Heart Failure

Treatments: Other: Combined exercise training; Other: High-intensity interval exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT02387411

not applied

Details and patient eligibility

About

Chronic heart failure (CHF) is a clinical syndrome presented with central, cardiac deterioration as well as peripheral vascular and muscular abnormalities, resulting finally to reduced exercise tolerance, quality of life and mortality rates. Exercise training is a major component of rehabilitation / secondary prevention interventions, inducing significant beneficial changes in mechanisms of pathophysiology, exercise tolerance, functional capacity and quality of life, while a positive impact on hospitalization and mortality reduction should not be also excluded. There has been growing interest in the characteristics and modalities of exercise training able to induce optimal benefits. High intensity and interval mode have been shown to induce greater benefits than moderate intensity and continuous mode regimes. Additionally, there has been sound rationale for the inclusion of strength training, which has been also shown able to yield benefits in terms of exercise capacity and quality of life. However, there haven't been much data on the so called combined regimes, which include both aerobic exercise and strength training. This study aims at investigating the effects of combined high-intensity interval and strength training compared to high-intensity interval exercise alone in CHF.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• stable heart failure
• ejection fraction <=45%
• optimal medical treatment
• NYHA class <=III

Exclusion criteria

• contraindications for maximal cardiopulmonary exercise testing (CPET)
• moderate to severe COPD
• inability to follow exercise programs due to orthopaedic problems

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Interval group

Active Comparator group

Description:

high-intensity interval exercise training

Treatment:

Other: High-intensity interval exercise training

Combined group

Active Comparator group

Description:

combined exercise training

Treatment:

Other: Combined exercise training