High Interval Versus Moderate Intensity Continuous Training on Soluble st2 Biomarkers in Chronic Heart Failure

Cairo University (CU)

Status: Completed

Conditions: Heart Failure

Treatments: Other: HIITS; Other: MICT

Study type: Interventional

Funder types: Other

Identifiers

NCT06647667

P.T.REC/012/004017

Details and patient eligibility

About

This study was designed to compare between the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on soluble ST2 biomarkers among chronic heart failure patients, also measure the improvement in the quality of life with different modes of exercise and with of it is more benifitial for the heart failure patient

Full description

The data concerned with the study including soluble ST2 biomarker levels, ejection fraction and MLHFQ was measured before and after twelve weeks of treatment.In this study a total sixty male patients with chronic heart failure NYHA class (I &II) were selected from the outpatient clinic, El-Demerdash hospital, Ain-shams University. Their age ranged from 50-60 years. Patients were randomly assigned into two groups, group A receiving HIIT along with prescribed medical treatment and group B receiving MCT along with prescribed medical treatment.

Enrollment: 60 patients

Sex: Male

Ages: 50 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patients selection was according to the following criteria:

  • Patients diagnosed with chronic heart failure (New York heart association class I& II) with systolic left ventricular dysfunction.
  • Their left ventricular ejection fraction (LVEF) <40%.
  • Medical treatment was optimized at least three months prior to study entry.
  • All patients didn't participate in any rehabilitation programs prior to the study.

Exclusion criteria

• Patients who had met one of the following criteria were excluded from the study:

  1. Signs of acute heart failure, unstable angina or severe arrhythmia three months prior to enrolment in the study.
  2. Pacemakers.
  3. Chronic obstructive pulmonary disease.
  4. Other disorders counteracting exercise testing conditions that limit lower limb mobility (for example, burns, fractures)
  5. Pre-existing neuromuscular diseases (for example Myasthenia Gravis).

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

group A

Experimental group

Description:

high intensity interval training

Treatment:

Other: HIITS

group B

Experimental group

Description:

moderate intensity continuous training

Treatment:

Other: MICT