High MAP in Septic Shock With Hypertension

Southeast University, China

Status: Completed

Conditions: Septic Shock

Treatments: Other: NE

Study type: Interventional

Funder types: Other

Identifiers

NCT01443494

SoutheastUChina2011ZDllKY03.0

Details and patient eligibility

About

We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.

Full description

The effect of mean arterial pressure (MAP) titration to higher level on microcirculation in septic shock patients with previous hypertension remains unknown. Our goal was to assess the effect of MAP titration to patients' usual level on microcirculation in septic shock patients with previous hypertension. We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.

Enrollment: 19 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with septic shock for less than 24 hours
• Fluid resuscitation was performed according to the guideline for treating septic shock to maintain the central venous pressure (CVP) for more than 8 mm Hg and central venous oxygen saturation for more than 70%
• Patients requiring norepinephrine (NE) to maintain a MAP of 65 mm Hg. Septic shock patients with fluid resuscitation after CVP > 8mmHg and mean blood pressure > 65 mmHg

Exclusion criteria

• Pregnancy
• Age < 18 years
• Inability to acquire the usual level of MAP
• Refusal of consent by the patient or relative
• Participation in other trials during the last three months
• Hypertensive patients without hypertension treatment

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

NE group

Experimental group

Description:

Adjust NE dose to titrate MAP to usual level regardless of fluid responsiveness when after EGDT.

Treatment:

Other: NE