High Nucleotide Meal Consumption in Uric Acid and Metabolic Health (TIDE)

University of Exeter

Status: Completed

Conditions: Healthy

Treatments: Other: High nucleotide meal; Other: Low nucleotide meal

Study type: Interventional

Funder types: Other

Identifiers

NCT03568864

170712/A/01

Details and patient eligibility

About

The production of protein rich animal products is associated with a large environmental burden, and with ethical considerations. Additionally, the over-consumption of meat might be associated with detrimental effects to health.

Using mycoprotein, a food ingredient derived from the fermentation of a fungus, as a meat substitute could result in environmental benefits, and could have a role in managing obesity, diabetes and improving metabolic health. However, naturally produced mycoprotein has a high nucleotide content and little is known about the impact of nucleotides in uric acid levels and other health markers.

The aim of this study is to investigate the effect of a meal based on nucleotide rich mycoprotein on uric acid concentrations and other markers of health.

Enrollment: 10 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 18 and 30

Exclusion criteria

• On medication (except contraception)
• Smokers
• Diagnosed with any metabolic or cardiovascular conditions
• BMI < 18 or > 30

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 2 patient groups, including a placebo group

Low nucleotide meal

Placebo Comparator group

Description:

Mixed meal containing mycoprotein with a reduced nucleotide content (\~ 2% nucleotides)

Treatment:

Other: Low nucleotide meal

High nucleotide meal

Experimental group

Description:

Mixed meal containing mycoprotein with a high nucleotide content (\~ 10% nucleotides)

Treatment:

Other: High nucleotide meal