High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD)

Mass General Brigham

Status

Completed

Conditions

ASA Triad

Asthma, Nasal Polyps, And Aspirin Intolerance

Treatments

Behavioral: Restricting daily intake of omega-6 fatty acids to less than 4 grams and increasing omega-3 fatty acids to 3 grams

Study type

Interventional

Funder types

Other

Identifiers

NCT02064738

2013-P002683

Details and patient eligibility

About

The purpose of this trial is to test the hypothesis that a treatment diet low in omega-6 fatty acids and high in omega-3 fatty acids can cause improvement in asthma symptoms, nasal symptoms, and pulmonary function in patients with aspirin-exacerbated respiratory disease (AERD).

Enrollment

10 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

History of physician-diagnosed asthma
History of nasal polyposis
History of at least two reactions to oral aspirin or other nonselective cyclooxygenase inhibitor with features of lower airway involvement (cough, chest tightness, wheezing, dyspnea), or diagnosis of AERD via a physician-conducted challenge to aspirin
Age between 18 and 70 years

Exclusion criteria

Current smoking, defined as daily tobacco smoking in the last 6 months and at least one instance of tobacco smoking in the last 3 months.
Current pregnancy or breastfeeding
BMI <20
History of allergy to fish or any unwillingness to eat fish as a regular part of the diet
Use of Zyflo (zileuton) in the last two weeks
Presence of an implantable cardioverter-defibrillator
Use of oral steroids in the last two weeks
Participation in any other clinical trial in the last month
Any use of nonsteroidal antiinflammatory drugs (NSAIDs) or any drug that inhibits the cyclooxygenase enzyme during the course of the study