High-protein and High-carbohydrate Diets' Effect on Urinary Concentrating Ability

Regional Hospital Holstebro

Status and phase: Completed; Phase 4

Conditions: Healthy

Treatments: Behavioral: High Protein diet; Behavioral: High carbohydrate diet

Study type: Interventional

Funder types: Other

Identifiers

NCT00282321

MED.RES.HOS.2006.01.TGK

Details and patient eligibility

About

We wanted to test urinary concentrating ability and AQP-2 expression in kidney during high-protein and high-carbohydrate diet.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• (1) Genders; both mal and female
• (2) Age; 18- 65 years old
• (3) BMI; below 30
• (4) Females had to bee in oral contraceptive treatment

Exclusion criteria

• (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs
• (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose)
• (3) Albuminuria or glucosuria
• (4) Cancer
• (5) Arterial hypertension
• (6) Alcohol abuse
• (7) Use of tobacco
• (8) Medical treatment, except oral contraceptives
• (9) Pregnancy or breast feeding
• (10) Medicine abuse
• (11) Donation of blood less than 1 month before the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)