High Protein Intake in Critically Ill Ventilated Patients

Cairo University (CU)

Status: Completed

Conditions: Intensive Care Unit Syndrome

Treatments: Dietary Supplement: Whey protein

Study type: Observational

Funder types: Other

Identifiers

NCT04977440

MS 29-2020

Details and patient eligibility

About

This prospective interventional randomized control study was conducted on forty patients with respiratory failure; all patients were intubated and mechanically ventilated for at least three days. Twenty patients received high protein intake using whey protein, with daily follow-up of the blood sugar level, serum electrolytes, and chemistry. ICU outcome regarding food intolerance, 30-day mortality, length of MV and ICU-stay was recorded

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 years
• Mechanically ventilated patients (for three days or more )

Exclusion criteria

• Age < 18 years old
• Contraindication for enteral nutrition (gut ischemia, obstruction, or perforation)
• Expected intolerance for enteral nutrition (paralytic ileus)
• Inability to start enteral nutrition within 24-hours(i.e. surgery or other interventions)
• Short bowel syndrome
• Hemodynamic instability ( i.e shock state, need for vasopressors )
• Child C liver cirrhosis or acute liver failure
• Dialysis dependency

Trial design

40 participants in 2 patient groups

standard protein

high protein

Treatment:

Dietary Supplement: Whey protein