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High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study

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Medical University of Vienna

Status

Completed

Conditions

Corneal Infiltrates
Corneal Abrasions

Treatments

Device: Optical Coherence Tomography (OCT)
Other: Slit lamp biomicroscopy

Study type

Interventional

Funder types

Other

Identifiers

NCT01753583
OPHT-041112

Details and patient eligibility

About

Corneal lesions such as corneal abrasions and corneal infiltrates are common in clinical practice. The current study seeks to investigate whether high-resolution OCT is suitable for imaging of these corneal lesions. The present study has the character of a pilot study and the results are intended to be used to develop a standardized protocol for imaging and analysis of these corneal lesions. Based on this protocol, further studies investigating the pathophysiology of corneal lesions or evaluating therapeutic success can be planned.

Enrollment

4 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Men and women aged over 18 years
  • Newly diagnosed corneal abrasion or corneal infiltrate

Exclusion criteria

  • Recurrent corneal erosion
  • Participation in a clinical trial in the previous 3 weeks
  • Presence of any abnormalities preventing reliable measurements as judged by the investigator
  • Any contraindication for topical application of Novain 0.4% eye drops for topical anesthesia or of Minims-Fluorescein Sodium eye drops for fluorescein staining
  • Pregnancy, planned pregnancy or lactating

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

4 participants in 2 patient groups

10 patients with corneal abrasions
Experimental group
Treatment:
Device: Optical Coherence Tomography (OCT)
Other: Slit lamp biomicroscopy
10 patients with corneal infiltrates
Experimental group
Treatment:
Device: Optical Coherence Tomography (OCT)
Other: Slit lamp biomicroscopy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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