High Resolution Micro OCT Imaging

The University of Alabama at Birmingham

Status

Active, not recruiting

Conditions

Covid19

Cystic Fibrosis

COPD

PCD - Primary Ciliary Dyskinesia

Sinusitis

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT03256773

F160125001

1R01HL116213 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis.

Full description

Lung Disease is the predominate cause of morbidity and mortality in patients with cystic fibrosis (CF). A better understanding of the primary pathogenesis of CF is essential in order to reveal the features that may lead to the onset of progressive lung disease. Discerning the nature of the CF defect could resolve longstanding controversy and result in a new therapeutic opportunity that may address pathophysiology. Recently the investigators have developed an innovative technology, termed 1-µm resolution optical coherence tomography (µOCT), which enables real-time cross-sectional microscopy of the functional epithelial surface of living airways.

Enrollment

60 estimated patients

Sex

All

Ages

14+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

THE INCLUSION CRITERIA:

Patients diagnosed with CF or healthy normal controls with no respiratory disease
Patients must be over the age of 14
Patient must be able to give informed consent

THE EXCLUSION CRITERIA:

Patients with recent respiratory infection requiring antibiotics or corticosteroids in the last 4 weeks (excluding routine perioperative antibiotics)
Patients with major sinus surgery that will alter the nasal anatomy and preclude imaging of the nares
Any condition that in the opinion of the investigator will alter the safety of pilot testing in the operating room
Female subjects who are pregnant