High Resolution Thermal Imaging to Identify Vertebral Fractures in Children and Young People With Osteogenesis Imperfecta (THERMOI)

NHS Foundation Trust

Status: Completed

Conditions: Osteogenesis Imperfecta

Treatments: Device: Thermal imaging device

Study type: Interventional

Funder types: Other

Identifiers

NCT04231916

SCH-13-067b

Details and patient eligibility

About

Brittle bone disease also known as osteogenesis imperfecta (OI) is characterised by a defect in the bone tissue that leads to recurrent fractures and significant bone deformities in children. These fractures include vertebral (spinal) fractures. As a result, child with OI require regular clinic surveillance that includes repeated xrays of the spine. in our pilot study the investigators plan to use a thermal imaging camera that can pick up changes in temperature to 0.03 degrees to determine whether the investigators can accurately identify vertebral fractures without the need for radiation. in the first part of the study the investigators will compare the thermal images from the camera with the xrays to see if the investigators can pick up the vertebral fractures seen on the xray picture. If this is possible, then the investigators will move on to phase 2 of the study which will investigate the ability of the thermal camera to pick up vertebral fractures without prior knowledge of where the fractures are located. If this approach is successful this will help us to develop a nonradiation, lowcost painless way of identifying vertebral fractures in children with OI.

Enrollment: 11 patients

Sex: All

Ages: 5 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Patients with Osteogenesis Imperfecta (with known vertebral fractures)for phase one of the study.
• Patients with Osteogenesis Imperfecta for phase 2 of the study
• In both groups patients will be aged 5 years and over

Trial design

11 participants in 1 patient group

Patients aged 5-18 years

Experimental group

Description:

Patients with Osteogenesis Imperfecta (with known vertebral fractures)for phase one of the study. Patients with Osteogenesis Imperfecta for phase 2 of the study In both groups patients will be aged 5 years and over

Treatment:

Device: Thermal imaging device