High-resolution Ultrasound in Lower Extremity Nerves and Common Fibular Neuropathies.

Sándor Beniczky

Status: Completed

Conditions: Ultrasonography; Peroneal Neuropathies

Treatments: Diagnostic Test: Ultrasound protocol

Study type: Observational

Funder types: Other

Identifiers

NCT03560505

USCF

Details and patient eligibility

About

This study establishes reference material of selected lower extremity nerves at pre-defined sites with high-resolution ultrasound. Furthermore in this study, high-resolution ultrasound of patients with common fibular compression neuropathy and patients with type 2 diabetic polyneuropathy involving the common fibular nerve will be examined and compared to healthy controls. High-resolution ultrasound measurements will be correlated with history, clinical information and electrophysiological data.

Full description

The usual diagnostic work-up of patients referred for lower-extremity neuropathy includes clinical examination, biochemical tests (blood and cerebrospinal fluid), electrophysiological assessment and if necessary nerve biopsy. The electrophysiological assessment usually consists of nerve conduction studies (NCS) and electromyography (EMG). While electrophysiological measurements generally give information about the function of nerves, high-resolution ultrasound may provide information about the structure of nerves.

High-resolution ultrasound examination has shown promising results as a supplementary tool in the diagnostic work-up of various peripheral neuropathies. The clinical utility of ultrasound in the diagnosis of common fibular neuropathies, however, calls for further elucidation.

This study establishes reference material of selected lower extremity nerves at pre-defined sites with high-resolution ultrasound. Furthermore in this study, high-resolution ultrasound of patients with common fibular compression neuropathy and patients with type 2 diabetic polyneuropathy involving the common fibular nerve will be examined and compared to healthy controls, as well as each other. High-resolution ultrasound measurements will be correlated with history, clinical information and electrophysiological data.

Enrollment: 90 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Type 2 diabetes polyneuropathy common fibular nerve affection or
• Common fibular nerve compression neuropathy

Exclusion criteria

• Lumbar radiculopathy
• Other competing lower extremity peripheral neuropathy
• Peripheral vascular disease
• Hypothyroidism

Trial design

90 participants in 2 patient groups

Common fibular compression neuropathy

Description:

Patients referred for electrophysiological assessment of common fibular compression neuropathy with subsequent confirmation of referral diagnosis. Intervention: Ultrasound protocol.

Treatment:

Diagnostic Test: Ultrasound protocol

Type 2 diabetes polyneuropathy

Description:

Patients with type 2 diabetes referred for polyneuropathy involving the common fibular nerve with subsequent confirmation of referral diagnosis. Intervention: Ultrasound protocol.

Treatment:

Diagnostic Test: Ultrasound protocol