High-Sensitive CRP and Carotid Stiffness Between Patients With and Without Coronary Slow Flow

Sohag University

Status

Completed

Conditions

Coronary Slow Flow

Carotid Stiffness

High-sensitivity C-reactive Protein

Treatments

Diagnostic Test: High-sensitivity C-reactive protein

Other: Stiffness Measurement

Study type

Observational

Funder types

Other

Identifiers

NCT07076745

Soh-Med-25-5-6PD

Details and patient eligibility

About

This study aims to compare the levels of high-sensitivity C-reactive protein (hs-CRP) and carotid artery stiffness between patients with coronary slow flow phenomenon (CSFP) and those with normal coronary flow.

Full description

The coronary slow flow phenomenon (CSFP) is characterized by delayed opacification of the coronary arteries during angiography in the absence of significant epicardial coronary artery disease.

Hypothesis: High-sensitivity C-reactive protein (hs-CRP) is a well-established biomarker of systemic inflammation and has been associated with various cardiovascular conditions. Elevated hs-CRP levels have been observed in patients with CSFP, suggesting an inflammatory component in its pathogenesis. This marker not only predicts future cardiovascular events but may also reflect ongoing vascular inflammation in patients with angiographically normal coronary arteries.

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥18 years old.
Both sexes.
Patients undergo coronary angiography for evaluation of chest pain or suspected ischemia.

Exclusion criteria

Pregnant or breastfeeding women.
History of cardiovascular events such as myocardial infarction or stroke.
Diagnosed autoimmune disorders, chronic hepatic or renal diseases.
Current or recent infections.
History of malignancy.
Patients taking medications known to affect inflammatory markers (e.g., corticosteroids or immunosuppressants).