High Sensitive Troponin T (hsTnT) and Copeptin as Prognostic Parameters in Patients With Elective Total Endoprosthesis

Heidelberg University

Status: Unknown

Conditions: Pulmonary Embolism; Perioperative Myocardial Infarctions

Study type: Observational

Funder types: Other

Identifiers

NCT01335815

TnT hs 3

Details and patient eligibility

About

Summary: The purpose of the study is to prove if the biomarker high sensitive troponin T (hsTnT) and the biomarker of endogenous stress copeptin can serve as surrogate parameter of prognosis in patients with elective knee and hip total endoprosthesis.

Full description

Consecutively, high sensitive troponin T and copeptin will be measured in all patients with elective knee and hip endoprosthesis in the orthopedic department of the University of Heidelberg. The blood is taken during the routine blood testes if possible, on admission and the days 1-4 following the operation. Usual baseline characteristics are taken as well as usual blood results (hb, cholesterol and so on). Primary endpoint is the detection of perioperative myocardial infarction and pulmonary embolism.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Consecutive patients with elective knee and hip endoprosthesis

Exclusion criteria

• Not willing or not able to take part in the observational trial
• No written inform consent

Trial design

200 participants in 1 patient group

elective knee and limb endoprothesis