High-sensitivity C-reactive Protein and United Kingdom Prospective Diabetes Study (UKPDS) Risk Score in Type 2 Diabetes

Korea University

Status: Completed

Conditions: Type 2 Diabetes; Atherosclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT01099865

PET(DM)

Details and patient eligibility

About

The UKPDS risk score is recommended to assess global risk for future coronary heart disease (CHD) events in primary prevention. Recently, high-sensitivity C-reactive protein (hsCRP) has emerged as a strong independent risk factor for CHD. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising imaging technique for the evaluation of vascular inflammation that reflects vulnerable atherosclerotic plaque.

Enrollment: 56 patients

Sex: All

Ages: 16 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes

Exclusion criteria

• Myocardial infarction, unstable angina, stroke, peripheral artery disease, or cardiovascular revascularization
• Resting blood pressure ≥160/100 mmHg
• Malignancy, or severe renal or hepatic disease
• Participants were free of any lipid-lowering therapies and postmenopausal hormone replacement therapy at least the 6 month period prior to enrollment
• History of inflammatory condition or those taking medications that might affect inflammatory status within 6 months