High Versus Low Blood-Pressure Target in the Post Operative Care of Liver Transplantation A Randomized, Controled, Open and Unicentric Trial. (LIVER-PAM)

University of Sao Paulo General Hospital

Status and phase: Completed; Phase 3

Conditions: Liver Transplant; Complications

Treatments: Other: Usual Care; Other: Usual Care + High Target of Mean Arterial Pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT05068713

LIVER-PAM

Details and patient eligibility

About

LIVER PAM

A randomized, controled, open and unicentric trial comparing high (MAP 85-90 mmHg) and low (65-70 mmHg) target of mean arterial pressure in the first 24 hours after liver transplantation.

Enrollment: 174 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Older than 18 y
• Admitted in the ICU for a post operative care after liver transplant

Exclusion criteria

• Consent refusal
• Liver transplant due to acute liver failure
• Renal transplant ( Previous or concomitant)
• Refusal from the healthcare provider responsible for the patient
• Renal substitution therapy in the prior 15 days
• Pregnancy
• Re-Transplant (Liver transplant in the previous 6 month)
• Hepatorenal syndrome current treatment (Use of terlipressin + Albumin)
• Refractory and persistent shock during or after transplant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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174 participants in 2 patient groups

Hihg Target Mean Arterial Pressure

Experimental group

Description:

Target of mean arterial pressure of 85-90 mmHg in ther first 24h after liver transplant.

Treatment:

Other: Usual Care + High Target of Mean Arterial Pressure

Low Target Mean Arterial Pressure

Active Comparator group

Description:

Target of mean arterial pressure of 65-70 mmHg in ther first 24h after liver transplant.

Treatment:

Other: Usual Care