High Versus Low Frequency rTMS on Motor Dysfunction in PD

Assiut University

Status: Completed

Conditions: Parkinson Disease

Treatments: Device: rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT03342846

High versus low TMS in PD.

Details and patient eligibility

About

The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study.

The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.

Full description

The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study.

The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week and 2 days off per week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.

Enrollment: 40 patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All PD patients who were diagnosed according to UK bank criteria for PD.

Exclusion criteria

• History of repeated head injury.
• History of repeated cerebrovascular strokes
• History of defined encephalitis
• Oculogyric crisis, supra nuclear gaze palsy.
• Family history of more than one relative
• severe dementia, MMSE < 23, severe depression
• Cerebellar signs
• Babiniski sign
• Hydrocephalus or intracranial lesion on neuroimaging
• Patients with intracranial on neuroimaging
• Patients with intracranial metallic device or pacemaker
• Patients who were unable to give informed consent because of severe anesthesia, or cognitive deficit

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

High Frequency rTMS in PD

Active Comparator group

Description:

The first group received 20 Hz rTMS on M1 daily for 10 days 5 sessions every week.

Treatment:

Device: rTMS

Low Frequency rTMS in PD

Active Comparator group

Description:

The second group received 1 Hz rTMS on M1 daily for 10 days 5 sessions every week.

Treatment:

Device: rTMS