High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure (HiLo)

University of Alberta

Status: Completed

Conditions: Heart Failure

Treatments: Other: Low SpO2; Other: High SpO2

Study type: Interventional

Funder types: Other

Identifiers

NCT02518828

HiLo-HF- 2 Pilot Trial

Details and patient eligibility

About

The primary objective of this pilot trial is to determine whether inpatients presenting to the Emergency Department (ED) with symptoms suggestive of Acute Heart Failure (AHF), who receive supplemental oxygen adjusted at either a high (SpO2 range ≥96%) or low (SpO2 range 90-92%) oxygen saturation level, leads to greater reduction in N-terminal-proBNP (NT-proBNP) at 72 hours.

Full description

Patients will be randomized to either a high (SpO2 range ≥96%) or low (SpO2 range 90-92%) oxygen after informed consent.

Enrollment: 50 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• >40 years of age presenting to the ED with AHF
• objective finding of HF (BNP >400 pg/ml or Chest X-Ray with pulmonary congestion)
• plan to admit with primary diagnosis as HF
• must be able to be randomized within 16 hours of presenting to the ED
• provided written informed consent

Exclusion criteria

• on home oxygen
• known prior hypercapnic failure (PaCO2 >50 mmHg)
• asthma
• primary pulmonary hypertension,
• patients who require urgent positive pressure ventilation or intubation
• patients on >10 L/min oxygen

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

High SpO2

Active Comparator group

Description:

In the high SpO2 set-point arm, patients will have a nasal cannula placed and will be manually titrated to SpO2 range ≥96%

Treatment:

Other: High SpO2

Low SpO2

Active Comparator group

Description:

In the low SpO2 set-point arm, patients will have a nasal cannula placed and will be manually titrated to SpO2 range 90-92%

Treatment:

Other: Low SpO2