High Volumes of Hypertonic Saline and Chest Physiotherapy in CF Patients

Haukeland University Hospital

Status: Completed

Conditions: Cystic Fibrosis

Treatments: Procedure: Physiotherapy; Device: Hypertonic saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01943890

2009/2125

Details and patient eligibility

About

Background Nebulised hypertonic saline (HS) is an established basic airway clearance treatment in Cystic Fibrosis (CF). However, there is scarce evidence regarding the practical implementation and administration of different HS volumes, including physiotherapy and aspects of breathing pattern.

The aim of the study was to implement standardised and age-adjusted nebulised volumes of hypertonic saline in cystic fibrosis patients, included in physiotherapy and lung drainage techniques.

Full description

Aims: To establish a safe, efficient routine for implementation of HS in daily treatment and to investigate the efficiency and tolerance of high volumes of HS integrated with chest physiotherapy.

HS was given twice daily with volumes of 4,5 ml in children aged 0-5 years, 6 ml at age 6-16 years and 9 ml at age > 16 years. The protocol included guidance of standardized breathing pattern, upright and sideways positioning and voluntary cough.

Enrollment: 8 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cystic fibrosis

Exclusion criteria

• Non-adherence

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

Physiotherapy and hypertonic saline

Experimental group

Description:

Chest physiotherapy integrated with inhalation of hypertonic saline

Treatment:

Procedure: Physiotherapy

Device: Hypertonic saline