Highly Sensitive Serum Cardiac Troponin T and Cardiovascular Events in Patients With Systemic Lupus Erythematosus (TROPOPLUS)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Systemic Lupus Erythematosus

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04580108

NI17026J

Details and patient eligibility

About

Identification of biological markers able to better stratify cardiovascular risks in systemic lupus erythematosus patients is needed. We aimed to determine whether serum cardiac troponin T levels measured with a highly sensitive assay (HS-cTnT) may predict cardiovascular events in systemic lupus erythematosus.

Full description

Cardiac Troponin (cTnT) is a marker of myocyte necrosis and injury in the early phase of acute myocardial infarction. Measured with high-sensitivity (HS) assays, HS-cTnT has proven predictive value for coronary heart disease, heart failure, and mortality in the general population at apparent low-risk for cardiovascular events. In a previous study, our group showed that HS-cTnT concentration was associated with subclinical atherosclerosis in systemic lupus erythematosus patients. The aim of this study was to determine whether HS-cTnT was associated with incident cardiovascular events in systemic lupus erythematosus

Enrollment: 446 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with a systemic lupus erythematosus

Exclusion criteria

• Inadequate follow-up period (< 20 months) -past history of CVE at baseline for inclusion in the TROPOPLUS study

Trial design

446 participants in 1 patient group

Patients with systemic lupus erythematosus

Description:

Patients with systemic lupus erythematosus enrolled in the PLUS cohort between 2007 and 2010