HIIT in Sedentary Obese Adults: Effects on Metabolic Risk, Body Composition, and FABP4

Eastern Mediterranean University

Status: Enrolling

Conditions: High-Intensity Interval Training

Treatments: Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06973980

YDIREL

Details and patient eligibility

About

It is aimed to investigate the responses of Fatty Acid Binding Protein 4 (FABP4), which has been discovered as a novel biomarker of obesity and metabolic diseases, to regular exercise training.

The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults.

Full description

Fatty acid binding proteins are intracellular proteins involved in the transport of fatty acids and are particularly associated with lipolytic activity. These proteins constitute a group of molecules that regulate intracellular lipid responses and are linked to metabolic and inflammatory pathways.

Studies have shown that FABP4 is associated with hypertension, insulin resistance, obesity, and stroke.

Inhibition of FABP4 synthesis has emerged as a promising strategy for the treatment of obesity-related conditions, particularly insulin resistance and diabetes, and it is emphasized that exercise models to suppress FABP4 should be further investigated.

The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults.

Hypotheses:

H01: HIIT has no effect on cardiometabolic risk factors in sedentary obese adults.

H02: HIIT has no effect on body composition in sedentary obese adults. H03: HIIT has no effect on plasma FABP4 levels in sedentary obese adults.

Enrollment: 28 estimated patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged between 20 and 35 years,
• BMI between 30 and 35 kg/m²,
• Waist circumference of 90-100 cm for women, 105-110 cm for men,
• Sedentary lifestyle (<600 MET-min/week),
• Referred by a physician (with a statement confirming no contraindication to exercise)."

Exclusion criteria

• BMI > 35,
• Pregnancy,
• Cardiovascular Diseases: Individuals with serious cardiovascular issues, such as uncontrolled hypertension, heart failure, coronary artery disease, or a heart attack within the last 6 months, which could pose a risk during exercise.
• Respiratory Diseases: Individuals with chronic respiratory conditions, such as uncontrolled or severe asthma or COPD, who cannot tolerate exercise due to their condition.
• Neurological Disorders: Individuals with neurological issues that limit exercise capacity, such as Parkinson's disease, stroke, or multiple sclerosis.
• Musculoskeletal Issues: Individuals with chronic musculoskeletal problems, particularly knee or hip osteoarthritis, that may increase the risk of pain or injury during exercise.
• Metabolic or Endocrine Disorders: Individuals with uncontrolled metabolic issues, such as diabetes or thyroid disorders, that could cause blood sugar or hormonal fluctuations during exercise.
• Acute Infections or Illness: Individuals with acute infections, fever, or recently undergone surgical procedures.
• Any health condition that may prevent participation in exercise."

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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28 participants in 2 patient groups

Exercise Group

Experimental group

Description:

High-Intensity Interval Training (HIIT) 1-minute interval, 1-minute active recovery 5-minute warm-up, 3-minute cool-down at 60% of peak heart rate. Weeks 1-2: Intensity at 85% of peak heart rate during work, active recovery at 60% of peak heart rate, 4 sets of 1-minute work. Weeks 2-7: Intensity at 90% of peak heart rate during work, active recovery at 60% of peak heart rate, 6 sets of 1-minute work. Weeks 8-12: Intensity at 90% of peak heart rate during work, active recovery at 60% of peak heart rate, 8 sets of 1-minute work.

Treatment:

Other: Exercise

Control Group

No Intervention group

Description:

No intervention will be applied to the control group.