Hip Denervation and Intra-articular Hydration in Damaged Hip in Axial Spondyloarthritis Patients

Sohag University

Status and phase: Completed; Phase 3

Conditions: Age > 18; Patients With Unilateral or Bilater Hip Damage According to BASRI Score; Patients With Axial SpA According to ASAS Criteria

Treatments: Drug: hip denervation; Drug: intra-articular hydration; Drug: Combined group; Drug: Control group

Study type: Interventional

Funder types: Other

Identifiers

NCT05219084

SC 250

Details and patient eligibility

About

Background: The hip joint is frequently affected in axial spondyloarthritis (SpA) of adults with destructive effects in untreated patients. About 35% of axial SpA patients had either unilateral or bilateral hip arthritis. Destruction is more common with early-onset, active disease, or enthesitis.

Objectives: The aim of this study is to evaluate the effect of hip denervation (HD) and intra-articular hydration (IAH) on pain, function score, hip mobility scores in a cohort of axial SpA patients with grade 3 and 4 hip BASRI scores.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18 or more
• Axial; SpA fulfilled ASA criteria
• BASRI score grade 3 or 4 for one hip at least

Exclusion criteria

• patients younger than 18
• Axial; SpA with normal hip or hip involvement less than 3 on BASRI score

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 4 patient groups, including a placebo group

placebo group

Placebo Comparator group

Description:

5ml of normal; saline-injected subcutaneously

Treatment:

Drug: Control group

Hip denervatiopn

Active Comparator group

Description:

Hip denervation with lidocaine 2% to each genicular branch, 2ml at each point

Treatment:

Drug: hip denervation

Inra-articular hydration

Active Comparator group

Description:

10 ml of normal saline injected inside the hip under ultrasound guidance

Treatment:

Drug: intra-articular hydration

compined group

Active Comparator group

Description:

hip denervation and intra-articular hydration were conducted together in this group

Treatment:

Drug: Combined group