Hip Denervation in Juvenile Idiopathic Arthritis With Hip Arthritis

Sohag University

Status and phase: Completed; Phase 3

Conditions: Hip Arthritis; Juvenile Idiopathic Arthritis

Treatments: Drug: Placebo; Drug: Steroid; Drug: Lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT04775225

3012020

Details and patient eligibility

About

Patients having juvenile idiopathic arthritis (according to ILAR criteria) with hip arthritis were divided into 3 groups. Group 1 received hip denervation and group 2 controlled and received a subcutaneous injection of saline, and group 3 received intra-articular triamcinolone. Outcome measures included pain, tenderness, range of motion, SOLAR, HARISS score. These outcomes were measured at baseline, 2 weeks, and 16 weeks

Full description

The aim of the study is to test the effect of denervation of the active hip in JIA and compare it with a placebo without changing systemic treatment during the study. Outcome measures included pain, range of motion, SOLAR score, and Harris functional score.

Enrollment: 120 patients

Sex: All

Ages: 2 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with JIA with unilateral hip arthritis

Exclusion criteria

• hip involvement due to other causes including
• septic arthritis
• other connective tissue diseases
• Avascular necrosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 3 patient groups, including a placebo group

Hip denervation group

Active Comparator group

Description:

This group will receive Lidocaine 2% block of the femoral and obturator genicular branches.

Treatment:

Drug: Lidocaine

control group

Placebo Comparator group

Description:

this group will receive saline injection subcutaneously at the same places.

Treatment:

Drug: Placebo

Steroid

Active Comparator group

Description:

This group with receiving an intra-articular injection of 80mg triamcinolone

Treatment:

Drug: Steroid