HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial

McMaster University

Status

Completed

Conditions

Hip Fractures

Treatments

Other: Accelerated medical clearance and surgery

Study type

Interventional

Funder types

Other

Identifiers

NCT02027896

HIP ATTACK Trial v5.0

Details and patient eligibility

About

HIP ATTACK is an international randomized controlled trial of 3000 patients with a hip fracture that requires a surgical intervention. This trial will determine the effect of accelerated medical clearance and accelerated surgery compared to standard care on the 90-day risk of mortality and major perioperative complication (i.e., a composite of mortality, nonfatal myocardial infarction, nonfatal pulmonary embolism, nonfatal pneumonia, nonfatal sepsis, nonfatal stroke, and nonfatal life-threatening and major bleeding).

Enrollment

3,001 patients

Sex

All

Ages

45+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age ≥45 years; and
diagnosis of hip fracture during working hours with a low-energy mechanism (i.e., falling from standing height) requiring surgery.

Exclusion criteria

patients requiring emergent surgery or emergent interventions for another reason (e.g., subdural hematoma, abdominal pathology requiring urgent laparotomy, acute limb ischemia, other fractures or trauma requiring emergent surgery, necrotising fasciitis, coronary revascularization, pacemaker-implantation);
open hip fracture;
bilateral hip fractures;
peri-prosthetic fracture;
therapeutic anticoagulation not induced by a Vitamin K Antagonist, unfractionated heparin, (e.g., administration of therapeutic Low Molecular Weight Heparin (LMWH) (>6,000 u/24h) in the 24 hours prior to enrolment, or intake of any other non-reversible oral anticoagulant(s) for which there is no reversing agent available
patients on a therapeutic vitamin K antagonist with a history of heparin induced thrombocytopenia (HIT);
patients refusing participation; or
patients previously enrolled in the study.