Hip-Fracture Surgery on Patients in Clopidogrel Therapy

Hvidovre University Hospital

Status: Completed

Conditions: Hip Fracture

Treatments: Drug: Clopidogrel

Study type: Observational

Funder types: Other

Identifiers

NCT02391883

CLOP-HIPFX study

Details and patient eligibility

About

Patients in Clopidogrel therapy alone or in combination with acetylsalicylic acid (Dual Antiplatelet Therapy (DAPT) presenting with a hip-fracture represent the surgeon with the dilemma of putting the patient at risk of a major blood loss during and after surgery, or putting the patient at risk of a thromboembolic event after surgery. The investigators hypothesize that the risk of a major blood loss in patients that are still under the effect of Clopidogrel or DAPT during or after hip-fracture surgery is relatively low. The investigators have conducted a retrospective observational study on hip-fracture patients to test this hypothesis.

Enrollment: 356 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients operated with short intramedullary nail for hip-fractures, in the study period. (1st of Jan. 2011-31st of Dec. 2013)

Exclusion criteria

• patients operated >24 hours after admission, patients in other forms of anticoagulation medication except acetylsalicylic acid (including vitamin K antagonists, dipyridamole, dabigatran, apixaban and rivaroxaban), missing data on blood loss in patient chart, missing blood samples in the first 4 days and extra-national patients (follow up not possible). Patients operated on both sides during the inclusion period were only included with data on their latest operation.

Trial design

356 participants in 2 patient groups

Clopidogrel

Description:

Patients in Clopidogrel or Dual Antiplatelet Therapy (Clopidogrel+Acetylsalicylic acid) at the time of admission AND who are operated \<24 hours after admission.

Treatment:

Drug: Clopidogrel

Control

Description:

Patients NOT in anticoagulation treatment (Except acetylsalicylic acid) AND who are operated \<24 hours after admission.