Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis

Bakirkoy Dr. Sadi Konuk Training and Research Hospital

Status: Unknown

Conditions: Vomiting; Nausea; Markedly Reduced Food Intake; Severe Dehydration

Study type: Observational

Funder types: Other

Identifiers

NCT01987869

2013-88

Details and patient eligibility

About

Serotonin excretion was investigated in the nausea and vomiting associated with hiperemezis gravid arum.

Full description

The occurrence of severe nausea and vomiting of early pregnancy (hiperemezis gravid arum) is estimated between 0.3% to 1% of all pregnancies. Although hiperemezis gravid arum has been recognized for a long time, its pathophysiologic mechanisms are still poorly understood. Many theories have been advocated, but to date none of these have been convincing.

It has been demonstrated that the nausea and vomiting associated with increased in serotonin liberation. This has provided a rationale for the treatment of these symptoms with specific serotonin antagonists.

The aim of this trial was to investigate the possible relationship between hiperemezis gravid arum and serotonin liberation.

Enrollment: 90 estimated patients

Sex: Female

Ages: 15 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 6-14 week pregnant women
• nausea
• protracted vomiting
• inability to tolerate food intake accompanied by obvious dehydration
• severe enough to justify hospitalisation
• at least 2+ ketonuria on dipstick urinanalysis.

Exclusion criteria

• with metabolic disorders such as diabet, thyroid