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Hippocampal Plasticity of Young Adults With Childhood Adversity

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Mass General Brigham

Status

Completed

Conditions

Depression
Anxiety

Treatments

Behavioral: Stress Management Skill Building Program A
Behavioral: Stress Management Skill Building Program B

Study type

Interventional

Funder types

Other

Identifiers

NCT02816502
2016P000335

Details and patient eligibility

About

This study investigates the clinical and neural effects of stress management skill building programs for young adults with childhood adversity. The investigators will recruit a total of 60 young adults (21-35 years old) who will be randomized into two different stress management skill building programs, both of which are 8 weeks long. MRI and psychological assessments will be acquired from all subjects before and after the intervention programs in order to investigate changes in clinical symptoms (such as depression, anxiety and stress) and hippocampus structure and function as well as other neural changes.

Enrollment

73 patients

Sex

All

Ages

21 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • having childhood adversity
  • no history of psychiatric disorders of psychotic features or neurological disorders
  • verified age between 21-35 years old;
  • no suicidal attempts during the past six months;
  • being determined by the clinician to have the capability to comply with the program requirements and not detrimental to other participants in the group;
  • passing MRI eligibility criteria.
  • provided written informed consent to participate in this study;
  • committed to meeting the requirement of refraining from using marijuana or illicit drugs.

Exclusion criteria

  • psychosis
  • active suicidal attempts during the past 6 months
  • psychoactive substance abuse
  • MRI exclusion criteria

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

73 participants in 2 patient groups

Stress Management Skill Building Program A
Experimental group
Description:
An eight week skill building group in which subjects meet with the teacher and other students in the group once a week, and complete homework and practice log during the week.
Treatment:
Behavioral: Stress Management Skill Building Program A
Stress Management Skill Building Program B
Active Comparator group
Description:
An eight week skill building group in which subjects meet with the teacher and other students in the group once a week, and complete homework and practice log during the week.
Treatment:
Behavioral: Stress Management Skill Building Program B

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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