Hippocampal Prophylactic Cranial Irradiation for Small Cell Lung Cancer

Johns Hopkins Medicine

Status

Completed

Conditions

Small Cell Lung Cancer Limited Stage

Small-cell Lung Cancer

SCLC

Treatments

Radiation: Hippocampal-sparing Prophylactic Cranial Irradiation

Study type

Interventional

Funder types

Other

Identifiers

NCT01797159

J12127

NA_00078659 (Other Identifier)

Details and patient eligibility

About

The Investigators are looking to compare standard treatment for the management of small cell lung cancer (SCLC) which is prophylactic cranial Irradiation (PCI) (shown to be very good in patient survival) with cranial sparing PCI. Although standard of care PCI is successful in patient survival it also has neurologic side-effects. The Investigators are hoping the cranial sparing PCI has the same positive survival results with the added benefit of lowering neurological side-effects.

Full description

The standard of care in management of small cell lung cancer consists of chemotherapy plus thoracic radiation followed by prophylactic cranial irradiation (PCI) based on a randomized trial that demonstrated a significant improvement in overall survival (OS) with PCI. Unfortunately radiation therapy to the brain is associated with neurocognitive toxicity, which may be at least in part related to radiation induced injury to neural progenitor cells in the hippocampus. Both human and animal data suggest an inverse relationship between radiation dose to the hippocampus and performance on neuropsychological testing. We hypothesize that hippocampal sparing PCI will allow improved performance on tests of short term memory and executive function compared to a historical control (RTOG 0212) receiving the same dose of conventional PCI. The primary objective of this study is to evaluate performance on the Hopkins Verbal Learning Test-Revised for delayed recall at 6 months following hippocampal-sparing PCI relative to the historical control. Secondary objectives are to estimate: 1) composite cognitive function following hippocampal-sparing PCI relative to the historical control and 2) the rate of metastases in the hippocampus at 2 years following hippocampal-sparing PCI. The long term goal of this research is to reduce the long term sequelae of radiation therapy for both primary and metastatic brain tumors.

Enrollment

20 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient must have newly diagnosed and confirmed small-cell lung cancer (SCLC)
Patient must have a performance status of 1 or higher
Patients must not have received previous irradiation to the brain
Patients must have limited stage disease with complete response to chemotherapy and consolidative chest radiotherapy that was documented at least on standard chest x-rays within one month of study entry
Negative MRI or CT scan of the brain at least one month before protocol entry
Women of child-bearing potential must have a negative pregnancy test and also agree to use adequate contraceptives while on protocol
Patient must be able to understand and sign the informed consent document
Patient must be informed of the investigational aspect to this trial prior to singing the informed consent document

Exclusion criteria

Patients receiving prior external beam irradiation to the head or neck, including any form of stereotactic irradiation
Radiographic evidence of brain metastases and/or ipsilateral lung metastases/malignant pleural effusion
Planned concurrent chemotherapy or antitumoral agent during PCI
Concomitant malignancy or malignancy within the past five years other than nonmelanomatous skin cancer or carcinoma in situ of the cervix
Patients with minimal pleural effusion evident on chest X-ray; minimal pleural effusion visible on chest CT is allowed.
Patients with epilepsy requiring permanent oral medication
Patients must not have a serious medical or psychiatric illness that would, in the opinion of the investigator, prevent informed consent or completion of protocol treatment, and/or follow-up visits.
Patients may not take Memantine. This is the only eligibility criterion that has been added to those of RTOG 0212, since some physicians might now prescribe Memantine. This medication would not have been given at the time of enrollment on RTOG 0212 and its administration could confound the results of this study.