Histamine H1/H2 Receptors and Training Adaptations

University Ghent

Status: Completed

Conditions: Exercise Training; Physical Activity

Treatments: Drug: Famotidine; Drug: Fexofenadine Hydrochloride; Other: Lactose; Other: High-intensity interval training (HIIT)

Study type: Interventional

Funder types: Other

Identifiers

NCT04450134

HIST-TRAINING (BC-06009)

Details and patient eligibility

About

Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Enrollment: 19 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sedentary or low levels of physical activity
• Caucasian

Exclusion criteria

• Chronic diseases
• Medication use
• Smoking
• Excessive alcohol consumption
• Seasonal allergies

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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19 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

6 weeks high-intensity interval training + placebo intake

Treatment:

Other: High-intensity interval training (HIIT)

Other: Lactose

Blockade

Experimental group

Description:

6 weeks high-intensity interval training + histamine H1/H2 receptor blockade

Treatment:

Other: High-intensity interval training (HIIT)

Drug: Fexofenadine Hydrochloride

Drug: Famotidine