Histamines and Central Hemodynamics

University of British Columbia

Status: Enrolling

Conditions: Histamine; Exercise

Treatments: Other: Exercise Bout; Other: Placebo; Drug: Diphenhydramine hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT07285031

H25-01909

Details and patient eligibility

About

When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with exercise. When the actions of histamine, a molecule primarily known for its role in allergies, are blocked, there is an attenuated blood flow response following exercise. However, this effect has never been studied in the blood vessels that supply our lungs. The purpose of this study is to examine the effects of histamines on pulmonary hemodynamics following exercise.

Enrollment: 20 estimated patients

Sex: All

Ages: 19 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age: 19 - 39.
2. Willing to visit the lab on 3 separate occasions.

Exclusion criteria

1. Previously diagnosed heart condition,
2. Previously diagnosed lung condition (including asthma),
3. Previously diagnosed metabolic condition,
4. Currently smokers (cigarettes, electronic cigarettes, cannabis) or who have smoked within the last 3 months,
5. Resting blood pressure >140/90 mmHg,
6. Unable to obtain appropriate quality ultrasound images of the heart.,
7. Individuals without tricuspid regurgitation at rest to allow assessment of the primary outcome,
8. Pregnant or trying to become pregnant,
9. Breastfeeding,
10. Chronically take antihistamines (i.e. daily),
11. History of adverse reactions to antihistamines,
12. Never taken antihistamines previously,
13. Currently taking any medications (including oral contraceptives).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 2 patient groups, including a placebo group

Blockade + Exercise Bout

Experimental group

Description:

Participants will ingest histamine H1 receptor blockade before performing an exercise bout.

Treatment:

Drug: Diphenhydramine hydrochloride

Other: Exercise Bout

Placebo + Exercise Bout

Placebo Comparator group

Description:

Participants will ingest a placebo before an exercise bout.

Treatment:

Other: Placebo

Other: Exercise Bout