Histones and Free-plasma DNA After Cardiac Arrest

University of Aarhus

Status: Completed

Conditions: Heart Arrest; Hypothermia; Post Cardiac Arrest Syndrome

Treatments: Other: cardiac arrest

Study type: Observational

Funder types: Other

Identifiers

NCT02733146

AU170878

Details and patient eligibility

About

To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.

Enrollment: 42 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Out of hospital cardiac arrest of presumed cardiac cause
• Return of spontaneous circulation (ROSC)
• Glasgow Coma Score < 8
• Age > 18 years and < 80 years

Exclusion criteria

• >60 minutes from the circulatory collapse to ROSC
• Time interval > 4 hours from cardiac arrest to initiation of targeted temperature management
• Terminal illness
• Coagulation disorder
• Unwitnessed asystolia
• Cerebral performance category 3-4 before the cardiac arrest
• Severe persistent cardiogenic shock
• Pregnancy
• Persistent cardiogenic shock (systolic blood pressure < 80 despite inotropic treatment)
• New apoplexy or intracerebral hemorrhage
• Lack of consent from the relatives
• Lack of consent from the general practitioner
• Lack of consent from the patient if he/she wakes up and is relevant

Trial design

42 participants in 1 patient group

cardiac arrest patients

Description:

Patients who has suffered a cardiac arrest

Treatment:

Other: cardiac arrest