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Objectives:
Eligibility:
Design:
Full description
Background
-Kaposi sarcoma-associated herpesvirus (KSHV) inflammatory cytokine syndrome (KICS) is a newly recognized syndrome caused by KSHV. It is characterized by severe inflammatory symptoms including fevers, wasting, cytopenias, hypoalbuminemia, and hyponatremia, associated in some cases with lymphadenopathy or effusions, without pathological evidence of MCD. Patients with KICS exhibit elevated KSHV viral loads and cytokine dysregulation, with elevations of IL-6, IL-10, and a KSHV-encoded IL-6 homolog, viral IL-6.
Objective
-Assessment of the natural history of KSHV inflammatory cytokine syndrome (KICS), including the spectrum of clinical, laboratory and radiographic abnormalities seen in affected participants.
Eligibility
Adults of any HIV status with:
Participants with these characteristics will be further evaluated to identify those whose clinical and laboratory features are consistent with the KICS working case definition to be followed in the natural history phase of the study.
Design
-This is a single center natural history study with a cohort of up to 120 evaluable participants. Participants who meet the criteria for KICS will go onto a natural history arm, which permits observation for KICS with or without other concurrent KSHV-associated disorders. Participants who require KS and/or primary effusion lymphoma (PEL) treatment along with a KICS diagnosis will receive rational therapies for these conditions or be treated for their KS and/or PEL on a separate protocol while still followed on this study.
Enrollment
Sex
Ages
Volunteers
Inclusion and exclusion criteria
INCLUSION CRITERIA:
Age greater than or equal to18 Years.
Any HIV status.
At least two manifestations drawn from at least two of the categories (clinical symptoms, laboratory abnormalities and radiographic abnormalities), which are at least possibly attributable to KICS and are not readily explicable from known medical conditions in the participant:
Clinical symptoms (each at least grade 1 by CTCAE definitions)
Fever (>38 degrees C), chills or rigors
Fatigue or lethargy
Cachexia or edema
Cough, dyspnea, airway hyperreactivity, or nasal inflammation
Nausea, anorexia, abdominal pain or altered bowel habit
Athralgia or myalgia
Altered mental state
Neuropathy with or without pain
Laboratory abnormalities
Anemia (hemoglobin<12.0g/dL)
Thrombocytopenia (platelets<100,000 cells/microL)
Leukopenia (white cell count<4,000 cells/microL)
Hypoalbuminemia (albumin<3.5g/dL)
Hyponatremia (sodium<135mmol/L)
Coagulopathy (PT or PTT >1.5 times upper limit of normal)
Radiographic Abnormalities
Pathologic lymphadenopathy (at least five discrete nodes each >1cm in their longest dimension)
Splenomegaly (>12 cm in the longest dimension)
Hepatomegaly (>17cm in the longest dimension)
Body cavity effusions not caused by primary effusion lymphoma nor chylous effusions directly related to lymphatic infiltration by KS
C-reactive protein (CRP) >3mg/L.
Exposure risk for KSHV infection (including being a first or second generation immigrant from an endemic area, or male-to-male sexual activity) or evidence of KSHV infection demonstrated by one of:
Women of child-bearing potential (WOCBP) and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and after treatment (if received), according to drug requirements. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
EXCLUSION CRITERIA:
Note: In collaboration with LP, we have recently found that some participants with KICS but without a lymph node or splenic diagnosis of MCD have MCD-like cells in their effusions or circulating blood. This may in fact represent a newly recognized form of KSHV-MCD, but our analysis continues. While certain of these participants were historically included in this study, given this new understanding, they will not be entered on this protocol and removed if liquid MCD is diagnosed.
Primary purpose
Allocation
Interventional model
Masking
140 participants in 6 patient groups
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Central trial contact
Anaida Widell; Robert Yarchoan, M.D.
Data sourced from clinicaltrials.gov
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