Histotripsy (HistoSonics®) for Liver Tumours

The University of Hong Kong (HKU)

Status

Active, not recruiting

Conditions

Liver Tumour

Treatments

Radiation: Histotripsy

Study type

Interventional

Funder types

Other

Identifiers

NCT06579833

UW24-442

Details and patient eligibility

About

Histotripsy is a promising non-invasive technique that uses high-intensity ultrasound waves to disrupt tissue without damaging surrounding structures. It works by using high-intensity ultrasound waves to create microscopic bubbles within the tumour tissue. These bubbles rapidly expand and collapse, generating shock waves that disrupt the tissue. The technique is highly precise and can be targeted to specific areas of the liver, allowing for selective destruction of tumour cells while minimizing damage to healthy tissue. This study will enrol 20 patients with liver tumours (be it primary or secondary liver tumours), monitor their post-operative adverse events, and study the changes in tumour size and volume after treatment. Histotripsy will be performed under general anaesthesia, with real-time monitoring by ultrasound, and deliver high-intensity ultrasound waves in single session or multiple sessions. Similar to other minimal invasive treatments, patients will be admitted 1 day prior, then receive Histotripsy on the next day and stay overnight for observation. Patients will be discharged on the 3rd day if unremarkable. During the hospital stay, blood samplings will be taken for evaluation around 2-4 times in total depending on the length of hospital stay.

Enrollment

60 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Fit for general anaesthesia
Liver tumour size < 10cm
Solitary or multifocal
Primary liver tumour such as hepatocellular carcinoma or intrahepatic cholangiocarcinoma
Secondary liver tumour such as liver metastasis
Patients with operable or inoperable liver tumours
Liver transplant candidates awaiting for liver graft

Exclusion criteria