HIT in People With Type 1 Diabetes

Liverpool John Moores University

Status: Completed

Conditions: Type1diabetes

Treatments: Other: HIT; Other: MICT

Study type: Interventional

Funder types: Other

Identifiers

NCT03545841

T1D_PARTB

Details and patient eligibility

About

Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.

Full description

This study aimed to investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V ̇O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state.

Enrollment: 14 patients

Sex

Volunteers: No Healthy Volunteers

Inclusion criteria

• duration of type 1 diabetes >6 months
• basal bolus regimen
• no significant history of hyper- or hypoglycaemia (determined from medical history)

Exclusion criteria

duration of type 1 diabetes <6 months,

• insulin pump therapy
• significant history of hyper- or hypoglycaemia (determined from medical history)
• obesity (BMI >30 kg∙m-2)
• pregnancy or planning pregnancy
• uncontrolled hypertension (>180/100 mmHg)
• angina, autonomic neuropathy
• taking any medication that affects heart rate
• major surgery planned within 6 weeks of the study
• severe nonproliferative
• unstable proliferative retinopathy

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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14 participants in 2 patient groups

HIT training

Experimental group

Description:

6 weeks of high-intensity interval training (HIT)

Treatment:

Other: HIT

Moderate intensity training

Experimental group

Description:

6 weeks of moderate-intensity continuous training (MICT)

Treatment:

Other: MICT