HIT on Hypoglycemic Risk in Type 1 Diabetes (T1D)

Liverpool John Moores University

Status: Completed

Conditions: Type1diabetes

Treatments: Behavioral: high intensity interval training; Behavioral: moderate intensity continous training

Study type: Interventional

Funder types: Other

Identifiers

NCT03598400

T1D1

Details and patient eligibility

About

There is clear evidence that regular exercise improves wellbeing and reduces the risk of diabetes related complications in people with type 1 diabetes. However, many people with type 1 diabetes do not exercise regularly. The primary reason for this is fear of hypoglycaemia and loss of glycaemic control associated with exercise. This loss of glycaemic control is associated with traditional moderate intensity continous aerobic exercise advocated in the guidelines for exercise in people with type 1 diabetes. Recent work (unpublished) from our lab suggests high intensity interval training (HIT) may reduce the risk of hypoglycaemia in people with type 1 diabetes, however stronger evidence is needed before firm conclusions can be drawn.

Therefore, the aim of this study is to determine the effects of HIT on glycaemic control in people with type 1 diabetes compared to no exercise and traditional moderate intensity continous exercise.

24 people with type 1 diabetes will be recruited to complete a randomised counterbalanced cross over study comparing 3x 2-week interventions periods. During these intervention periods participant will maintain their habitual lifestyle but complete either no exercise (control), traditional moderate intensity continous exercise or high intensity interval training. Throughout the intervention periods participants glycaemic control will be monitored using a flash glucose monitor.

Enrollment: 11 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• T1D diagnosis more than 6 months ago (to ensure participants are out of the honeymoon period),
• Using a basal bolus insulin regime or insulin pump therapy
• BMI ≤ 32 kg.m-2

Exclusion criteria

• Pregnancy (or planning pregnancy)
• Disability preventing participation in an exercise regime
• Angina
• Autonomic neuropathy
• Medication that affects heart rate (this will affect estimation of fitness)
• Major surgery planned within 6 weeks of study
• Uncontrolled blood pressure
• Significant history of hyperglycaemia
• History of severe hypoglycaemia requiring third party assistance within the last 3 months
• Severe non-proliferative and unstable proliferative retinopathy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

11 participants in 3 patient groups

Control

No Intervention group

Description:

Participants will continue with their habitual lifestyle but perform no exercise for 2 weeks

Moderate intensity continous training

Active Comparator group

Description:

Participants will complete moderate intensity continous training during a 2 week intervention period

Treatment:

Behavioral: moderate intensity continous training

high intensity interval training

Experimental group

Description:

Participants will complete high intensity interval training during a 2 week intervention period

Treatment:

Behavioral: high intensity interval training