HIV-1 Non-group M in Cameroon : Study of Genotypic and Phylogenetic Diversity (OBSOCAM)

ANRS, Emerging Infectious Diseases

Status: Not yet enrolling

Conditions: HIV Infection

Treatments: Diagnostic Test: Prospective

Study type: Observational

Funder types: Other

Identifiers

NCT06913959

ANRS0098s

Details and patient eligibility

About

The aim of the study is to study the genotypic characteristics of HIV-1 non-M circulating in the whole Cameroon and their genetic evolution.

Full description

HIV-1 is divided four distinct groups: M (major) which represents the pandemic strains while others groups O (outlier), N (non M, non O) and P are called non-M variants. Group O (HIV-O) is more divergent, endemic in Central Africa and Cameroon, where it represents about 1% of HIV infections. These variants are characterized by an important genetic divergence from pandemic HIV-1 group M (HIV-M), which impacts on the diagnosis, monitoring and treatment of infected patients. Although discovered in 1990, and emerged at the same time as HIV-M, no data of epidemiology, natural history and evolution of the genetic diversity of these variants is currently available. The few knowledge available to date come from sporadic cases, mainly through studies in Yaoundé. It is therefore essential to improve current knowledge on these variants and their consequences on infected patients.

The aim of the study is to study the genotypic characteristics of HIV-1 non-M circulating in the whole Cameroon and their genetic evolution.

Enrollment: 220 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All available samples tested positive for HIV during the national Health survey of Cameroon in 2011 And 2018
• All Individuals who came to Centre Pasteur in Yaoundé or Garoua for HIV screening or viral load monitoring.

Exclusion criteria

• Insufficient quantity or degraded Dried Blood Spot samples
• All HIV-positive individuals aged less than 21 years, infected with a Group M HIV-1 virus, or those who refused to participate in the study

Trial design

220 participants in 2 patient groups

Retrospective

Description:

Dried Blood Spot samples tested positive for HIV during the previous national epidemiologic surveys Demographic health surveys in Cameroon

Treatment:

Diagnostic Test: Prospective

Prospective

Description:

Individuals who came to Center Pasteur in Yaounde or Garoua for HIV screening or viral load monitoring

Treatment:

Diagnostic Test: Prospective