HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 1

Yale University

Status: Completed

Conditions: Alcohol Use; HIV

Treatments: Behavioral: IMB-motivational interviewing (MI) techniques (IMB-MI)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05560932

P01 AA029545-03 sub 9238 (Other Grant/Funding Number)

P01AA029545-03 (U.S. NIH Grant/Contract)

Justice 090622

Details and patient eligibility

About

This pilot intervention will consist of a brief intervention for patients with HIV who take 5 or more medications and currently (within the past month) consume alcohol. The focus of this pilot will be on bothersome symptoms and the impact of alcohol use and medications on these symptoms. The rationale is that any alcohol use may interact with medications in serious ways leading to adverse outcomes, including bothersome symptoms.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• participants in both Veterans Aging Cohort Study (VACS) and Medications, Alcohol, and Substance use in HIV (MASH) studies
• prescribed 5 or more medications AND who either have a positive PEth value (8+) or a self-reported AUDIT-C value consistent with current alcohol use (score >0)

Exclusion criteria

• Alcohol use disorder (AUD) diagnosis in the past 12 months or who test positive for AUD on the Alcohol Symptom Checklist for moderate or severe AUD (score of 4 or more)

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

HIV Medications and Alcohol Use

Experimental group

Description:

Participants with HIV who take 5 or more medications and currently (within the past month) consume alcohol

Treatment:

Behavioral: IMB-motivational interviewing (MI) techniques (IMB-MI)