HLH Patients - a Retrospective Study

Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna

Status: Completed

Conditions: Hemophagocytic Lymphohistiocytoses

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT05531721

HLH-OIRM

Details and patient eligibility

About

Monocentric, observational, retrospective, no profit study aimed to analyze factors that are significantly impacting the outcome of patients diagnosed with HLH.

Full description

retrospective data collection to study: type of HLH familial vs secondary, sex, age, presence of infectious cause, involvement central nervous system ( SNC), hepatic involvement, presence of hemophagocytosis, presence of splenomegaly, presence of involvement of other organs, the value of neutrophils (PMN), the value of hemoglobin, platelets, albumin, triglycerides, ferritin, LDH, type of therapy and the response to therapy after 2 months

Enrollment: 39 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Have received HLH diagnosis according to HLH 2004 criteria
• age ⥶18 years.
• followed at our facility between January 2004 and December 2021
• Whose parents have consented to participation and data processing

Exclusion criteria

• The study does not foresee specific exclusion criteria other than the non-compliance with the inclusion criteria

Trial design

39 participants in 1 patient group

pediatric patients affected by hemophagocytic lymphohistiocytoses

Description:

pediatric patients with HLH

Treatment:

Other: Observation