HMG Stimulation Versus HRT for Endometrial Preparation Prior to Blastocyst Transfer in Moderate to Severe IUA Patients

Reproductive & Genetic Hospital of CITIC-Xiangya

Status: Completed

Conditions: Intrauterine Adhesion; Infertility, Female

Treatments: Drug: hormone replacement therapy; Drug: human menopausal gonadotrophin

Study type: Interventional

Funder types: Other

Identifiers

NCT03578172

KYXM-2018001

Details and patient eligibility

About

Evaluation of endometrial preparation using either human menopausal gonadotrophin (HMG) stimulation and hormone replacement therapy (HRT) prior to blastocyst transfer in patients with moderate to severe intrauterine adhesion (IUA).

Enrollment: 186 patients

Sex: Female

Ages: 20 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI 18~23 kg/m2
• Women with moderate to severe IUA as defined by the American Fertility Society classification (1988)
• Presence of at least 3 cryopreserved cleavage-stage embryos (including 1 good quality) or blastocysts

Exclusion criteria

• Using embryos from donor oocytes
• Preimplantation genetic diagnosis(PGD)/Preimplantation genetic screening(PGS) cycles
• Moderate or severe endometriosis
• Untreated unilateral or bilateral hydrosalpinx
• Uterine adenomyosis, uterine myoma (submucous,intramural myoma >4 cm),>1cm septate uterus, double uterus, bicornuate uterus, unicornuate uterus

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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186 participants in 2 patient groups

Experimental-HMG stimulation group

Experimental group

Description:

Women will be subjected to ovarian stimulation for endometrial preparation using human menopausal gonadotrophin before blastocyst transfer

Treatment:

Drug: human menopausal gonadotrophin

Control-HRT group

Active Comparator group

Description:

Women will be subjected to hormone replacement therapy for endometrial preparation before blastocyst transfer

Treatment:

Drug: hormone replacement therapy