HMGB1 in ICU-survivors

Karolinska University Hospital

Status: Completed

Conditions: Cognitive Impairment; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT02914756

EPN 2013/1221-31/1

Details and patient eligibility

About

Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?

Enrollment: 100 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male/Female age 18-17
• Expected ICU-stay more than 24 hours

Exclusion criteria

• Dont understand the language
• Substance abuse, alcohol or drugs
• Blind, deaf or suffering from aphasia
• Ongoing psychiatric illness or psychopharmacological treatment
• Suffering from dementia och mentally impaired
• Structured brain damage or meningitis
• Palliative Care
• ICU-treated for more than 48 hours
• Transferred from other ICU
• Being treated with ECMO
• Not having residency in Stockholm

Trial design

100 participants in 2 patient groups

Sepsis

Description:

Patients suffering from Severe sepsis or Septic chock at the ICU.

Non-Sepsis

Description:

Patients being treated at ICU but not suffering from severe sepsis/septic chock