HNC: Human Neural Circuits Electrophysiology During Cognition

Stanford University

Status and phase: Enrolling; Phase 1

Conditions: Psychiatric Disorder

Treatments: Drug: Ketamine Hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT05962424

70198

Details and patient eligibility

About

The purpose of this study is to understand how ketamine brings about dissociative symptoms.

Full description

The goal of this proposed research is to record the effects of ketamine on brain activity to understand the changes that occur during antidepressant therapy and the side effect of dissociation. This research is designed to probe altered cognitive states associated with dissociation, depression, and other neuropsychiatric conditions.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient in clinical neuro inpatient units at Stanford Medical Center
• Age >18 years old
• Female participants are expected to use an effective method of birth control throughout the study which includes: hormonal methods (birth control pills, patches, injections, vaginal ring or implants), barrier methods (condom or diaphragm) used with spermicide, intrauterine device (IUD), or abstinence (no sex)

Exclusion criteria

• Lifetime psychotic disorder
• Pregnant or nursing females
• Prior adverse ketamine response
• Use of ketamine in past 7 days

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 1 patient group

Ketamine

Experimental group

Description:

Study participants will receive 0.5mg/kg of ketamine - one single infusion

Treatment:

Drug: Ketamine Hydrochloride